M4 mAChR Modulator-2 [CAS 3062458-27-6]
M4 mAChR Modulator-2 [CAS 3062458-27-6]
SKU:QM-0013237
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Product Details
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Description
M4 mAChR Modulator-2 is an orally active, selective, brain-penetrant positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (M4 mAChR) (EC50 = 513 nM). M4 mAChR Modulator-2 exhibits high target selectivity, showing negligible affinity and low inhibition rates for non-target receptors (D1R/D2R/D3R, 5-HT subtypes, κ/δ/μ opioid receptors, H1, M1/M2) while specifically binding to M4 mAChR with a Ki of 377 nM and an inhibition rate of 62.8%. M4 mAChR Modulator-2 reverses Dizocilpine (MK-801) -induced hyperlocomotion in mice. M4 mAChR Modulator-2 can be used for the study of schizophrenia[1]
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CAS Number
[3062458-27-6]
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Molecular Formula
C26H24FN5O
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Molecular Weight
441.5
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Smiles
CC1=C2C(CN(C(CC3CN(C4=CC(C5=CC=C(C#N)C(F)=C5)=NC=C4)C3)=O)C2)=NC(C)=C1
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Target
MAChR
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Isoform
MAChR4
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Shipping Conditions
Room temperature
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M4 mAChR Modulator-2 [CAS 3062458-27-6]
M4 mAChR Modulator-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.