Microtubule inhibitor 12
Microtubule inhibitor 12
SKU:QM-0154211
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Product Details
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Description
Microtubule inhibitor 12 (Compound 2k) is an inhibitor for microtubule polymerization with an IC50 of 22.23 μM. Microtubule inhibitor 12 arrests the cell cycle of B16-F10 at G2/M phase, induces apoptosis in B16-F10, and inhibits cell migration. Microtubule inhibitor 12 inhibits the proliferation of cancer cells B16-f10, A549, HepG2 and MCF-7, with IC50s of 0.098, 0.135, 0.109, and 0.259 μM, respectively. Microtubule inhibitor 12 exhibits antitumor efficacy in mouse model[1].
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Molecular Formula
C22H22N4O3
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Molecular Weight
390.44
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Smiles
COC1=CC(NC2=NC(C3=C4C=CN(C4=CC=C3)C)=NC=C2)=CC(OC)=C1OC
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Target
Apoptosis; Microtubule/Tubulin
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Shipping Conditions
Room temperature
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Microtubule inhibitor 12
Microtubule inhibitor 12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.