MRGPRX1 agonist 4 [CAS 2764889-60-1]
MRGPRX1 agonist 4 [CAS 2764889-60-1]
SKU:QM-0065545
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Product Details
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Description
MRGPRX1 agonist 4 (compound 1t) is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can reduce behavioral heat hypersensitivity in a neuropathic pain model humanized MRGPRX1 mice. MRGPRX1 agonist 4 can be used for researching neuropathic pain[1].
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CAS Number
[2764889-60-1]
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Molecular Formula
C23H17Cl2F3N2O2S
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Molecular Weight
513.36
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Smiles
CC(C)(C1=C(C2=CC=C(C(Cl)=C2)Cl)C3=C(N=CN=C3OC4=C(C=CC=C4)OC(F)(F)F)S1)C
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Target
Mas-related G-protein-coupled Receptor (MRGPR)
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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MRGPRX1 agonist 4 [CAS 2764889-60-1]
MRGPRX1 agonist 4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.