Mrgx2 antagonist-3 [CAS 2641397-91-1]
Mrgx2 antagonist-3 [CAS 2641397-91-1]
SKU:QM-0013913-01
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Product Details
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Description
Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of MrgX2 receptor with an IC50 value of 0.042-2.5 nM. Mrgx2 antagonist-3 blocks downstream G protein signaling and β-Arrestin recruitment, thereby inhibiting MrgX2 receptor-mediated calcium influx and cellular degranulation. Mrgx2 antagonist-3 is promising for research of inflammation-related diseases and pruritus, such as chronic urticaria, allergic asthma[1].
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CAS Number
[2641397-91-1]
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Molecular Formula
C15H15F2N3O
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Molecular Weight
291.3
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Smiles
O=C1C(CC)=C(C(C)C)N=C2NC3=CC(F)=C(C=C3N12)F
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Target
Mas-related G-protein-coupled Receptor (MRGPR)
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Purity
98.09
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Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Room Temperature
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Mrgx2 antagonist-3 [CAS 2641397-91-1]
Mrgx2 antagonist-3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.