Multitarget AD inhibitor-2
Multitarget AD inhibitor-2
SKU:QM-0118265
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Product Details
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Description
Multitarget AD inhibitor-2 (Compound VN-19) is a multitargeting inhibitor acetylcholinesterase (AChE, IC50=0.14 μM), butyrylcholinesterase (BChE, IC50=11.6 μM), monoamine oxidase B (MAO B, IC50=0.45 μM). Multitarget AD inhibitor-2 inhibits self-induced aggregation of amyloid beta protein Aβ1-42 (inhibition rate is 47.3% at 20 μM), and downregulates the level of ROS in SH-SY5Y (80 inhibition rate at 25 μM). Multitarget AD inhibitor-2 ameliorates the cognitive decline in Scopolamine -induced Alzheimer’s Disease zebrafish models[1].
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Molecular Formula
C22H23NO4
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Molecular Weight
365.42
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Smiles
O=C1C=C(C2=CC=C(OCCN3CCCC3)C(OC)=C2)OC4=C1C=CC=C4
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Target
Cholinesterase (ChE) ; Monoamine Oxidase
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Isoform
AChE; BChE; MAO-B
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Shipping Conditions
Room temperature
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Multitarget AD inhibitor-2
Multitarget AD inhibitor-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.