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Necrosulfonamide [CAS 1360614-48-7]

Necrosulfonamide [CAS 1360614-48-7]

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QM-0079460-01

£117.25 GBP
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Product Details

  • Description

    Necrosulfonamide is a MLKL and Gasdermin D (GSDMD) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis, activate the Nrf2 pathway and the downstream antioxidant enzymes, and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways[1][2][3][4][5][6][7].

  • CAS Number

    [1360614-48-7]

  • Molecular Formula

    C18H15N5O6S2

  • Molecular Weight

    461.47

  • Smiles

    O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3

  • Target

    Caspase; Heme Oxygenase (HO) ; Interleukin Related; Keap1-Nrf2; Mixed Lineage Kinase; Necroptosis; NO Synthase; NOD-like Receptor (NLR) ; Pyroptosis; TNF Receptor

  • Isoform

    Caspase 1; HO-1; IL-1; IL-6; iNOS; NLRP3

  • Concentration

    10mM

  • Purity

    99.47

  • Solubility

    DMSO : ≥ 28 mg/mL

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H315, H319, H335

  • Precautions

    H302, H315, H319, H335
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Variant Variant total Quantity Price Variant total
5 mgQM-0079460-01
5 mgQM-0079460-01
£117.25/ea		 £0.00
£117.25/ea £0.00
10 mM - 1 mLQM-0079460-02
10 mM - 1 mLQM-0079460-02
£126.25/ea		 £0.00
£126.25/ea £0.00
10 mgQM-0079460-03
10 mgQM-0079460-03
£148.75/ea		 £0.00
£148.75/ea £0.00
25 mgQM-0079460-04
25 mgQM-0079460-04
£299.07/ea		 £0.00
£299.07/ea £0.00
50 mgQM-0079460-05
50 mgQM-0079460-05
£414.50/ea		 £0.00
£414.50/ea £0.00
100 mgQM-0079460-06
100 mgQM-0079460-06
£712.17/ea		 £0.00
£712.17/ea £0.00
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Necrosulfonamide [CAS 1360614-48-7]

Necrosulfonamide is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.