NLRP3 modulator 8 [CAS 3069891-88-6]
NLRP3 modulator 8 [CAS 3069891-88-6]
SKU:QM-0014510
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Product Details
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Description
NLRP3 modulator 8 (Compound 14) is a NLRP3 modulator. NLRP3 modulator 8 significantly degrades NEK7 with an DC50 of 9 nM. NLRP3 modulator 8 dose-dependently inhibits caspase-1 activity and IL-1β release in macrophages in response to NLRP3 inflammasome activation. NLRP3 modulator 8 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].
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CAS Number
[3069891-88-6]
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Molecular Formula
C20H19Cl2FN4O3
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Molecular Weight
453.29
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Smiles
O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C=N3)F)=O)C=C2Cl)Cl)=O
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Target
Caspase; Interleukin Related; NEKs; NOD-like Receptor (NLR)
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Isoform
Caspase 1; IL-1; NEK7
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Shipping Conditions
Room temperature
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NLRP3 modulator 8 [CAS 3069891-88-6]
NLRP3 modulator 8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.