NMDAR antagonist 5 [CAS 3038464-68-2]
NMDAR antagonist 5 [CAS 3038464-68-2]
SKU:QM-0011488
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Product Details
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Description
NMDAR antagonist 5 (Compound A17) is a multi-target antagonist against NMDAR and monoamine transporters (SERT、DAT and NET) . NMDAR antagonist 5 shows good NMDAR antagonistic potency (IC50 = 0.3 μM) and monoamine transporter activities (SERT IC50 = 1.1 μM、DAT IC50 = 0.7 μM、NET IC50 = 2.7 μM) . NMDAR antagonist 5 is highly safe and has low toxicity (hepatotoxicity and nephrotoxicity (IC50 > 100 μM) ; cardiotoxicity (IC50 = 24.5 μM) ) . NMDAR antagonist 5 has antidepressant effects and can be used in the study of depression[1].
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CAS Number
[3038464-68-2]
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Molecular Formula
C17H21N3
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Molecular Weight
267.37
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Smiles
C1([C@]2(N3CCCC3)CC(C=NN4)=C4CC2)=CC=CC=C1
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Target
Dopamine Transporter; iGluR; Monoamine Transporter; Serotonin Transporter
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Isoform
NMDA Receptor
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Shipping Conditions
Room temperature
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NMDAR antagonist 5 [CAS 3038464-68-2]
NMDAR antagonist 5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.