Nrf2 activator-21 [CAS 1912404-14-8]
Nrf2 activator-21 [CAS 1912404-14-8]
SKU:QM-0013252
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Product Details
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Description
Nrf2 activator-21 is a Nrf2 activator with dual antioxidant and neuroprotective properties. Nrf2 activator-21 binds to Keap1 Kelch domain and disrupts Keap1-Nrf2 interactions and activate antioxidant defense mechanisms. Nrf2 activator-21 reduces apoptosis and decreases caspase-3 activity in the hippocampal neurons. Nrf2 activator-21 targets cerebral ischemia/reperfusion injury (CIRI) via Nrf2 pathway activation. Nrf2 activator-21 improves neurological function, alleviates anxiety-like behavior, enhances memory in rats with 2-vessel occlusion (2VO) -induced CIRI. Nrf2 activator-21 can be used for the study of cerebral ischemia/reperfusion injury[1].
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CAS Number
[1912404-14-8]
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Molecular Formula
C19H14O5
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Molecular Weight
322.31
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Smiles
COC1=CC=C2C(OC(C(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)=O)=C1
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Target
Apoptosis; Caspase; Keap1-Nrf2
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Shipping Conditions
Room temperature
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Nrf2 activator-21 [CAS 1912404-14-8]
Nrf2 activator-21 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.