NSD2/H3K36me2 modulator-1
NSD2/H3K36me2 modulator-1
SKU:QM-0016011
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Product Details
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Description
NSD2/H3K36me2 modulator-1 is an orally active NSD2/H3K36me2 modulator. NSD2/H3K36me2 modulator-1 competitively binds to the SAM pocket of NSD2, potently inhibits NSD2 expression and suppresses H3K36me2 methylation. NSD2/H3K36me2 modulator-1 reverses epithelial-mesenchymal transition (EMT), inhibits cell migration, and induces G0/G1 phase arrest and apoptosis. NSD2/H3K36me2 modulator-1 induces decreased Mitochondrial membrane potential (MMP) and subsequent Reactive oxygen species (ROS) generation. NSD2/H3K36me2 modulator-1 can be used to research the NSD2-targeting epigenetic anticancer strategies for hepatocellular carcinoma (HCC) [1].
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Molecular Formula
C41H59ClN2O5
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Molecular Weight
695.37
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Smiles
ClC1=CC(N(CC(N[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@@]4([H])C[C@@H](O)[C@@]5([H])[C@@]3(C)CC[C@]5([H])[C@@]6(C)CCCC(C)(C)O6)(C)[C@]4(C)CC2)=O)C(C7=O)=O)=C7C=C1
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Target
Apoptosis; Histone Methyltransferase; Reactive Oxygen Species (ROS)
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Isoform
NSD2/MMSET/WHSC1
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Shipping Conditions
Room temperature
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NSD2/H3K36me2 modulator-1
NSD2/H3K36me2 modulator-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.