Nur77 agonist-1 [CAS 2899254-71-6]
Nur77 agonist-1 [CAS 2899254-71-6]
SKU:QM-0011498
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Product Details
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Description
Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. Nur77 agonist-1 induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression. Nur77 agonist-1 has binding affinity to the ligand binding domain (LBD) of Nur77 (KD: 13.80 μM) . Nur77 agonist-1 exhibits significant antiproliferative activity against a variety of breast cancer cells (IC50: 2.15-3.26 μM) and has low toxicity to normal cells. Nur77 agonist-1 can be used in breast cancer research[1].
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CAS Number
[2899254-71-6]
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Molecular Formula
C24H18ClN5O2
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Molecular Weight
443.89
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Smiles
O=C(NC1=CC=C(C(N/N=C/C2=CC=CC(Cl)=C2)=O)C=C1)NC3=CC4=CC=CN=C4C=C3
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Target
Ferroptosis; Glutathione Peroxidase; Nuclear Hormone Receptor 4A/NR4A; Reactive Oxygen Species (ROS)
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Isoform
GPX4
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Shipping Conditions
Room temperature
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Nur77 agonist-1 [CAS 2899254-71-6]
Nur77 agonist-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.