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Nurr1 agonist 12

Nurr1 agonist 12

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QM-0011147-01

£1,179.95 GBP
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Product Details

  • Description

    Nurr1 agonist 12 (Compound 37) is the agonist for nuclear receptor-associated protein 1 (Nurr1) that activates the transcriptional activity of Nurr1 with an EC50 of 0.06 μM. Nurr1 agonist 12 activates the human response elements NBRE, NurRE, and DR5 with EC50 of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Nurr1 agonist 12 induces the expression of Nurr1-regulated neurotrophic genes, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin) . Nurr1 agonist 12 exhibits neuroprotective efficacy against Paraquat-induced neurotoxicity[1].

  • Molecular Formula

    C18H12ClN3O

  • Molecular Weight

    321.76

  • Smiles

    O=C(C1=C(Cl)C=C2C=CNC2=C1)NC3=CC4=C(C=CC=C4)N=C3

  • Target

    Nuclear Hormone Receptor 4A/NR4A

  • Isoform

    Nurr1/NR4A2

  • Purity

    99.62

  • Solubility

    DMSO : 100 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature
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Variant Variant total Quantity Price Variant total
5 mgQM-0011147-01
5 mgQM-0011147-01
£1,179.95/ea		 £0.00
£1,179.95/ea £0.00
10 mgQM-0011147-02
10 mgQM-0011147-02
£1,744.92/ea		 £0.00
£1,744.92/ea £0.00
25 mgQM-0011147-03
25 mgQM-0011147-03
£2,422.89/ea		 £0.00
£2,422.89/ea £0.00
50 mgQM-0011147-04
50 mgQM-0011147-04
£3,131.24/ea		 £0.00
£3,131.24/ea £0.00
100 mgQM-0011147-05
100 mgQM-0011147-05
£3,897.91/ea		 £0.00
£3,897.91/ea £0.00
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Nurr1 agonist 12

Nurr1 agonist 12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.