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Nurr1 agonist 9
Nurr1 agonist 9
SKU:QM-0108227
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Product Details
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Description
Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM) . Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable[1].
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Molecular Formula
C21H19ClN4O2
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Molecular Weight
394.85
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Smiles
CC1=C(NC(C2=CC=C(C3=CC=C(N(C)C)C=C3)O2)=O)N(C=CC=C4Cl)C4=N1
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Target
Nuclear Hormone Receptor 4A/NR4A
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Isoform
Nurr1/NR4A2
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Shipping Conditions
Room temperature
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Nurr1 agonist 9
Nurr1 agonist 9 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.