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Orexin receptor antagonist 4 [CAS 2251017-69-1]
Orexin receptor antagonist 4 [CAS 2251017-69-1]
SKU:QM-0066934
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Product Details
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Description
Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1) [1].
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CAS Number
[2251017-69-1]
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Molecular Formula
C23H25FN4O2
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Molecular Weight
408.47
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Smiles
[H][C@@]12CN(C[C@@]1(CN([C@H]2C)C(C3=CC=C(C=C3F)OC)=O)[H])C4=NC(C)=C(C(C)=C4)C#N
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Target
Orexin Receptor (OX Receptor)
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Isoform
OX1 Receptor; OX2 Receptor
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Orexin receptor antagonist 4 [CAS 2251017-69-1]
Orexin receptor antagonist 4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.