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PI3K/mTOR Inhibitor-8 [CAS 2492376-85-7]
PI3K/mTOR Inhibitor-8 [CAS 2492376-85-7]
SKU:QM-0066683
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Product Details
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Description
PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase[1].
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CAS Number
[2492376-85-7]
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Molecular Formula
C23H22N8O4S
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Molecular Weight
506.54
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Smiles
O=C(C1=CC2=NC(C3=CN=C(N)N=C3)=NC(N4CCOCC4)=C2S1)NNC(C5=CC=C(OC)C=C5)=O
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Target
MTOR; PI3K
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Isoform
MTOR; PI3Kα
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PI3K/mTOR Inhibitor-8 [CAS 2492376-85-7]
PI3K/mTOR Inhibitor-8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.