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Piezo1 agonist 1-d2 [CAS 3058199-62-2]
Piezo1 agonist 1-d2 [CAS 3058199-62-2]
SKU:QM-0121294-01
£1,217.62 GBP
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Product Details
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Description
Piezo1 agonist 1-d2 (Compound 12a) is an agonist for Piezo1 with an EC50 of 2.21 μM. Piezo1 agonist 1-d2 activates the Ca2+-related ERK signaling pathway, and thus promotes the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) . Piezo1 agonist 1-d2 ameliorates disuse osteoporosis in the hindlimb-unloading (HU) rat model[1].
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CAS Number
[3058199-62-2]
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Molecular Formula
C16H13D2Cl2N5OS2
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Molecular Weight
430.37
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Smiles
ClC1=C(C(Cl)=CC=C1)C([2H])(SC2=NN=C(S2)C3=CN=C(C=N3)NC[C@@H](C)O)[2H]
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Target
ERK; Piezo Channel
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Shipping Conditions
Room temperature
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Piezo1 agonist 1-d2 [CAS 3058199-62-2]
Piezo1 agonist 1-d2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.