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Pim-1/2 kinase inhibitor 2 [CAS 2918764-16-4]
Pim-1/2 kinase inhibitor 2 [CAS 2918764-16-4]
SKU:QM-0072921
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Product Details
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Description
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines[1].
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CAS Number
[2918764-16-4]
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Molecular Formula
C25H19ClN4O3
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Molecular Weight
458.9
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Smiles
N#CC1=C(C2=CC3=CC(Cl)=CC=C3N=C2N4CCOCC4)C=C(C5=CC=CC(O)=C5)NC1=O
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Target
Pim
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Isoform
PIM1; PIM2
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Pim-1/2 kinase inhibitor 2 [CAS 2918764-16-4]
Pim-1/2 kinase inhibitor 2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.