PKC-theta inhibitor 1 [CAS 1160501-81-4]
PKC-theta inhibitor 1 [CAS 1160501-81-4]
SKU:QM-0141836-01
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Product Details
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Description
PKC-theta inhibitor 1 is an orally active and selective ATP-competitive inhibitor of Protein Kinase Cθ (PKCθ), with a Ki value of 6 nM. PKC-theta inhibitor 1 inhibits T-cell-mediated inflammatory responses by suppressing the release of proinflammatory cytokines (IL-2 IC50 = 0.21 μM in anti-CD3/CD28-stimulated PBMCs; IL-17 IC50 = 1 μM in CD3/CD28-stimulated Th17 cells) PKC-theta inhibitor 1 significantly reduces symptoms in mice with ongoing experimental autoimmune encephalomyelitis (EAE) . PKC-theta inhibitor 1 can be used for the study of T-cell-mediated inflammatory diseases such as multiple sclerosis[1].
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CAS Number
[1160501-81-4]
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Molecular Formula
C17H15F3N4O
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Molecular Weight
348.32
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Smiles
NCC1(C2=CC=CC(C3=C4C(NN=C4C(F)(F)F)=NC=C3)=C2)COC1
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Target
Interleukin Related; PKC
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Isoform
PKCα; PKCδ; PKCθ
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Purity
99.73
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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PKC-theta inhibitor 1 [CAS 1160501-81-4]
PKC-theta inhibitor 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.