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PPARδ agonist 11 [CAS 2982696-04-6]
PPARδ agonist 11 [CAS 2982696-04-6]
SKU:QM-0120048
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Product Details
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Description
PPARδ agonist 11 (Compound 11) is a selective agonist for PPARδ with an EC50 of 20 nM. PPARδ agonist 11 reduces the levels of nitrite oxide (NO), proinflammatory cytokines TNFα and IL-6 in LPS -stimulated RAW264.7 cell, and exhibits anti-inflammatory efficacy via NF-κB pathway. PPARδ agonist 11 exhibits good stability in human liver microsomes and plasma. PPARδ agonist 11 ameliorates Carrageenan (HY-125474) -induced foot edema[1].
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CAS Number
[2982696-04-6]
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Molecular Formula
C19H15F3N2O3S2
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Molecular Weight
440.46
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Smiles
CC1=CC(SCC(S2)=NN=C2C3=CC=C(C(F)(F)F)C=C3)=CC=C1OCC(O)=O
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Target
PPAR
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Isoform
PPARα; PPARβ/δ
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Shipping Conditions
Room temperature
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PPARδ agonist 11 [CAS 2982696-04-6]
PPARδ agonist 11 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.