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PPARγ agonist 19
PPARγ agonist 19
SKU:QM-0013712
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Product Details
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Description
PPARγ agonist 19 (Compound 5e) is a PPARγ agonist. PPARγ agonist 19 has an IC50 of 11.27 μM against COX-1 and an IC50 of 0.05 μM against COX-1. PPARγ agonist 19 increases glucose uptake in rat hemidiaphragm assay and is superior to pioglitazone. PPARγ agonist 19 alleviates hyperglycemia and insulin resistance in an in vivo model of type 2 diabetes in rats and protects against renal and lipidemia damage caused by metabolic dysfunction[1].
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Molecular Formula
C20H17N5O5S3
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Molecular Weight
503.57
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Smiles
O=S(C1=CC=C(N2N=NC(COC3=CC=C(/C=C(SC(N4)=S)/C4=O)C=C3OC)=C2)C=C1)(N)=O
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Target
COX; PPAR
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Isoform
COX-1; COX-2; PPARγ
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Shipping Conditions
Room temperature
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PPARγ agonist 19
PPARγ agonist 19 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.