PPAR agonist 7
PPAR agonist 7
SKU:QM-0015604
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Product Details
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Description
PPAR agonist 7 is an orally active pan-PPAR agonist, demonstrating potent activation of all three subtypes, PPARα (EC50 = 1.51 μM), PPARδ (EC50 = 1.11 μM), and PPARγ (EC50 = 3.14 μM). PPAR agonist 7 significantly enhances glucose uptake in adipocytes while exhibiting minimal adipogenic activity. PPAR agonist 7 can suppress PPARγ Ser273 phosphorylation in white adipose tissue and upregulate insulin-sensitizing genes. PPAR agonist 7 does not cause weight gain or fluid retention in high-fat diet (HFD) / Streptozotocin (STZ) -induced type 2 diabetes mellitus (T2DM) models. PPAR agonist 7 has selective modulation of PPAR signaling pathways without activation of adipogenic gene programs. PPAR agonist 7 can be used for the study of diabetes[1].
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Molecular Formula
C29H35NO5
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Molecular Weight
477.59
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Smiles
CC(C)(OC1=C(C)C=C(/C=C2OC3=CC(NCC4CC4)=CC=C3C\2=O)C=C1C)C(OC(C)(C)C)=O
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Target
Adenosine Receptor; Endogenous Metabolite; Fatty Acid Synthase (FASN) ; PPAR
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Shipping Conditions
Room temperature
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PPAR agonist 7
PPAR agonist 7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.