Rheb inhibitor NR1 [CAS 2216763-38-9]
Rheb inhibitor NR1 [CAS 2216763-38-9]
SKU:QM-0141318-01
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Product Details
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Description
Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1 μM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1) . Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity[1]. (Rheb-IVK: Rheb-dependent mTORC1 kinase activity)
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CAS Number
[2216763-38-9]
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Molecular Formula
C25H19BrCl2N2O3S
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Molecular Weight
578.3
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Smiles
O=C(C(N1CC2=CC=C(C(N(C)C)=O)C=C2)=CC3=C1C=C(SC4=CC=C(Cl)C(Cl)=C4)C=C3Br)O
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Target
MTOR
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Concentration
10mM
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Purity
99.26
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319
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Precautions
H302, H315, H319
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Rheb inhibitor NR1 [CAS 2216763-38-9]
Rheb inhibitor NR1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.