RSL3 [CAS 1219810-16-8]
RSL3 [CAS 1219810-16-8]
SKU:QM-0079159-01
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Product Details
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Description
RSL3 ((1S,3R) -RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells[1].
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CAS Number
[1219810-16-8]
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Molecular Formula
C23H21ClN2O5
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Molecular Weight
440.88
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Smiles
O=C([C@H]1CC2=C([C@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC
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Target
Ferroptosis; Glutathione Peroxidase; p62; Reactive Oxygen Species (ROS)
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Isoform
GPX4
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Purity
99.87
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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RSL3 [CAS 1219810-16-8]
RSL3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.