Gefitinib [CAS 184475-35-2]
Gefitinib [CAS 184475-35-2]
SKU:QM-0156498-01
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Product Details
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Description
Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis, which can be used for cancer related research, such as Lung cancer and breast cancer [1][2][5].
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CAS Number
[184475-35-2]
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Molecular Formula
C22H24ClFN4O3
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Molecular Weight
446.9
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Smiles
ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCN4CCOCC4)=C1)F
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Target
Apoptosis; Autophagy; EGFR
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Isoform
EGFR/ErbB1/HER1
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Purity
99.99
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H318, H351, H360, H373, H401, H402, H410
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Precautions
H302, H315, H318, H351, H360, H373, H401, H402, H410
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Gefitinib [CAS 184475-35-2]
Gefitinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.