S1P1 agonist 7
S1P1 agonist 7
SKU:QM-0013520
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Product Details
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Description
S1P1 agonist 7 is a potent, orally active, and β-arrestin-biased S1P1 agonist (EC50 (G‑protein) = 12.7 nM and EC50 (β‑arrestin) = 3.23 nM) . S1P1 agonist 7 demonstrates potent immunomodulatory activity and a favorable safety profile. S1P1 agonist 7 exhibits excellent metabolic stability, minimal to moderate CYP inhibition, and S1P3-sparing selectivity. S1P1 agonist 7 shows pharmacokinetics, effectively reduces circulating lymphocytes, and significantly alleviates disease severity in experimental autoimmune encephalomyelitis (EAE) mouse models under both prophylactic and therapeutic regimens. S1P1 agonist 7 can be used for multiple sclerosis (MS) research[1].
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Molecular Formula
C23H22N2O5
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Molecular Weight
406.43
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Smiles
O=C(O)CCC(N1C=CC2=C1C=CC(OCC3=CC=C(OC(C)C)C(C#N)=C3)=C2)=O
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Target
LPL Receptor
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Shipping Conditions
Room temperature
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S1P1 agonist 7
S1P1 agonist 7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.