S1P1 agonist III [CAS 1324003-64-6]
S1P1 agonist III [CAS 1324003-64-6]
SKU:QM-0142345-01
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Product Details
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Description
S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3. IC50 value: 18 nM (EC50) Target: S1P1 agonist When dosed orally at 1 and 3 mg/kg, the azahydroxymethyl analogue 22 achieved statistically significant lowering of circulating blood lymphocytes 24 h postdose. In rats, a dose-proportional increase in exposure was measured when 22 (HY-12835) was dosed orally at 2 and 100 mg/kg. 22 displayed excellent pharmacokinetic parameters with low clearance (CL = 0.11 L/h/kg), long mean residence time (40 h), and good oral bioavailability (F = 67%).
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CAS Number
[1324003-64-6]
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Molecular Formula
C21H16F3N3O3
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Molecular Weight
415.37
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Smiles
COC1=CC=NC=C1C(NC(NC2=CC(C(F)(F)F)=C(C3=CC=CC=C3)C=C2)=O)=O
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Target
LPL Receptor
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Purity
99.64
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Solubility
DMSO : 62.5 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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S1P1 agonist III [CAS 1324003-64-6]
S1P1 agonist III is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.