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Sigma-1 receptor antagonist 5 [CAS 2952808-33-0]
Sigma-1 receptor antagonist 5 [CAS 2952808-33-0]
SKU:QM-0068293
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Product Details
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Description
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative with analgesic activity, is an antagonist of sigma receptor (Ki=4.5 nM (σ1R), 10 nM (σ2R) ) and histamine H3 (hH3R, Ki=7.7 nM, IC50=215 nM) . Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models[1].
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CAS Number
[2952808-33-0]
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Molecular Formula
C26H27N3O
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Molecular Weight
397.51
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Smiles
N#CC1=CC=C(C2=CC=C(OCCCN3CCC(C4=CC=NC=C4)CC3)C=C2)C=C1
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Target
Histamine Receptor; Sigma Receptor
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Sigma-1 receptor antagonist 5 [CAS 2952808-33-0]
Sigma-1 receptor antagonist 5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.