STING agonist-45 [CAS 2361424-97-5]
STING agonist-45 [CAS 2361424-97-5]
SKU:QM-0014480
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Product Details
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Description
STING agonist-45 is a selective STING agonist (EC50 = 0.28 μM) . STING agonist-45 activates the innate immune response through the cGAS-STING pathway, upregulating key markers such as p-TBK1 and IRF3. STING agonist-45 exhibits robust STING activation in human peripheral blood mononuclear cells (PBMCs), inducing the production of type I interferons (such as IFN-β) and downstream cytokines (such as TNF-α and IL-6) . STING agonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8+ T cell infiltration in mouse models. STING agonist-45 is promising for the study of STING-related diseases[1][2].
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CAS Number
[2361424-97-5]
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Molecular Formula
C21H26N6O4
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Molecular Weight
426.47
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Smiles
O=C(C1=CC2=C(C(OC3COC3)=C1)N(CCC)C(NC(C4=CC(C)=NN4CC)=O)=N2)N
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Target
Cyclic GMP-AMP Synthase; IFNAR; Interleukin Related; STING; TNF Receptor
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Shipping Conditions
Room temperature
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STING agonist-45 [CAS 2361424-97-5]
STING agonist-45 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.