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THR-β agonist 10
THR-β agonist 10
SKU:QM-0013343
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Product Details
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Description
THR-β agonist 10 is an orally active and selective THR-β agonist, with an EC50 of 11 nM. THR-β agonist 10 significantly reduces ALT (Alanine Aminotransferase), TC (Total Cholesterol), and LDL-C (Low-Density Lipoprotein Cholesterol) levels, and improves steatosis, ballooning, inflammation and fibrosis in the metabolic dysfunction-associated steatohepatitis (MASH) mouse model. THR-β agonist 10 can be used for the study of MASH[1].
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Molecular Formula
C25H13Cl2N7O3
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Molecular Weight
530.32
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Smiles
O=C1NC(N(C2=CC(Cl)=C(N3C=CC4=C3C=CC(N4CC5=CC=C(C#N)C=C5)=O)C(Cl)=C2)N=C1C#N)=O
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Target
Thyroid Hormone Receptor
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Shipping Conditions
Room temperature
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THR-β agonist 10
THR-β agonist 10 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.