THR-β agonist 9 [CAS 2920045-74-3]
THR-β agonist 9 [CAS 2920045-74-3]
SKU:QM-0012479
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Product Details
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Description
THR-β agonist 9 is a potent, selective, and His435 mutation-sensitive THR-β (EC50: 3.2 nM) agonist. THR-β agonist 9 has moderate selectivity (approximately 10-fold) and good activation capacity (EC50: 134.2 nM to 515.5 nM) for multiple His435 mutants (H435A, H435Y, and H435R) . THR-β agonist 9 has the potential to be used in the study of dyslipidemia, metabolic dysfunction-associated steatohepatitis (MASH), or resistance to thyroid hormone (RTH) [1].
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CAS Number
[2920045-74-3]
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Molecular Formula
C23H18N2O6
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Molecular Weight
418.4
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Smiles
OC1=C(C(NCC(O)=O)=O)N=C(OC)C2=CC(OC3=CC=C4C(C=CC=C4)=C3)=CC=C21
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Target
Acetyl-CoA Carboxylase; AMPK; Mitochondrial Metabolism; Thyroid Hormone Receptor
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Shipping Conditions
Room temperature
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THR-β agonist 9 [CAS 2920045-74-3]
THR-β agonist 9 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.