TLR7/8 agonist 13 [CAS 1402802-45-2]
TLR7/8 agonist 13 [CAS 1402802-45-2]
SKU:QM-0014453
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Product Details
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Description
TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (lowest effective concentrations (LEC) [hTLR7] = 1.6 μM) and TLR8 (LEC [hTLR8] = 1.6 μM) . TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells (hPBMCs) (LEC [hPBMC] = 0.5 μM) . TLR7/8 agonist 13 induces endogenous IFNα, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus[1].
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CAS Number
[1402802-45-2]
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Molecular Formula
C12H22N4O2
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Molecular Weight
254.33
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Smiles
NC(N=C1N[C@H](CCO)CCCC)=NC=C1OC
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Target
HBV; IFNAR; Interleukin Related; Toll-like Receptor (TLR)
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Isoform
TLR7; TLR8
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Shipping Conditions
Room temperature
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TLR7/8 agonist 13 [CAS 1402802-45-2]
TLR7/8 agonist 13 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.