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TLR7 agonist 29 [CAS 2275612-76-3]
TLR7 agonist 29 [CAS 2275612-76-3]
SKU:QM-0011189
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Product Details
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Description
TLR7 agonist 29 (Compound 1) is the agonist for TLR7 with an EC50 of 5.2 nM for human TLR7 (EC50 for mouse TLR7 is 48.2 nM) . TLR7 agonist 29 activates bone marrow-derived macrophages (BMDMs), stimulates myeloid cells in the tumor microenvironment, promotes the expression of PD-L1, CD86 and IFN-α. TLR7 agonist 29 can be used as payload for synthesis of ADC[1].
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CAS Number
[2275612-76-3]
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Molecular Formula
C20H27N7O2
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Molecular Weight
397.47
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Smiles
NC1=C2C(N(CC3=CN=C(CNC4CCC4)C=C3)C(O)=N2)=NC(OCCCC)=N1
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Target
ADC Payload; IFNAR; PD-1/PD-L1; Toll-like Receptor (TLR)
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Isoform
TLR7
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Shipping Conditions
Room temperature
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TLR7 agonist 29 [CAS 2275612-76-3]
TLR7 agonist 29 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.