Topoisomerase I/II inhibitor 6
Topoisomerase I/II inhibitor 6
SKU:QM-0102881
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Product Details
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Description
Topoisomerase I/II inhibitor 6 (compound 3i) is a potent inhibitor of topoisomerase I and II with IC50s of 4.77 and 15 µM, respectively. Topoisomerase I/II inhibitor 6 shows antiproliferative activities against human melanoma LOX IMVI cancer cell line with IC50 values of 26.7 and 25.4 µM, respectively. Topoisomerase I/II inhibitor 6 provokes substantial levels of early, late apoptosis and increases the expression level of active caspase-3[1].
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Molecular Formula
C31H28F2N4O6S
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Molecular Weight
622.64
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Smiles
FC1=CC=C(/C([H])=C2SC(N(CCCC(N3CCN(C4=C(F)C=C5C(N(C6CC6)C=C(C(O)=O)C5=O)=C4)CC3)=O)C\2=O)=O)C=C1
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Target
Apoptosis; Topoisomerase
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Isoform
Topo I; Topo II
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Shipping Conditions
Room temperature
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Topoisomerase I/II inhibitor 6
Topoisomerase I/II inhibitor 6 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.