Topoisomerase I/II inhibitor 8 [CAS 355400-87-2]
Topoisomerase I/II inhibitor 8 [CAS 355400-87-2]
SKU:QM-0008876
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Product Details
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Description
Topoisomerase I/II Inhibitor 8 (Compound Ru7) is a dual catalytic inhibitor of Topoisomerase I/II, capable of inducing DNA damage and PARP-1 activation, which subsequently leads to the activation of RIPK1, RIPK3, and MLKL, ultimately triggering necroptosis. Topoisomerase I/II Inhibitor 8 demonstrates remarkable anticancer activity by effectively targeting the nuclei of cancer cells and inducing cell death through necroptosis, showing great clinical potential in circumventing drug resistance in cancer treatment[1].
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CAS Number
[355400-87-2]
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Molecular Formula
C14H11Br2NO5S2
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Molecular Weight
497.18
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Smiles
O=C(CN1C(/C(SC1=S)=C/C2=CC(OCC)=C(C(Br)=C2Br)O)=O)O
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Target
Mixed Lineage Kinase; Necroptosis; PARP; RIP kinase; Topoisomerase
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Shipping Conditions
Room temperature
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Topoisomerase I/II inhibitor 8 [CAS 355400-87-2]
Topoisomerase I/II inhibitor 8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.