Topoisomerase I inhibitor 17 [CAS 2413582-45-1]
Topoisomerase I inhibitor 17 [CAS 2413582-45-1]
SKU:QM-0121815
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Product Details
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Description
Topoisomerase I inhibitor 17 (Compound 7h) is a Topoisomerase I (Top1) inhibitor. Topoisomerase I inhibitor 17 reduces DDX5 and reverses the locking of Top1 activity by DDX5. Topoisomerase I inhibitor 17 induces Top1-mediated DNA damage and promotes reactive oxygen species (ROS) production. Topoisomerase I inhibitor 17 induces Apoptosis (reduces antiapoptotic proteins XIAP, Bcl-2, Survivin and up-regulates pro-apoptotic proteins Bax, γH2AX) . Topoisomerase I inhibitor 17 also blocks the progression of the G2/M checkpoint and induces cell cycle arrest. Topoisomerase I inhibitor 17 significantly inhibits colony formation and cell migration in colorectal cancer cells. Topoisomerase I inhibitor 17 effectively reduces tumors in human PDX tumor mice[1].
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CAS Number
[2413582-45-1]
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Molecular Formula
C28H21FN2O7
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Molecular Weight
516.47
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Smiles
FC(C=CC(C1=C2C(C(N3C2)=CC([C@@](CC)4O)=C(C3=O)COC4=O)=NC5=CC6=C(C=C51)OCO6)=C7)=C7OC
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Target
Apoptosis; Bcl-2 Family; DNA/RNA Synthesis; IAP; Reactive Oxygen Species (ROS) ; Survivin; Topoisomerase
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Isoform
Bax; Bcl-2; Topo I; XIAP
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Shipping Conditions
Room temperature
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Topoisomerase I inhibitor 17 [CAS 2413582-45-1]
Topoisomerase I inhibitor 17 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.