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Topoisomerase II inhibitor 3 [CAS 99140-25-7]
Topoisomerase II inhibitor 3 [CAS 99140-25-7]
SKU:QM-0065210
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Product Details
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Description
Topoisomerase II inhibitor 3 (Compound 6 h) is a acridone derivatives, as well as a Type II DNA topoisomerase (topo II) inhibitor , as a topo IIα/β inhibitor with the value of IC50 is 0.17 μM for topo IIα and the value of IC50 is 0.23 μM for topo IIβ subtypes, caused obvious DNA damage, and induced apoptosis by triggering the loss of mitochondrial membrane potential[1].
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CAS Number
[99140-25-7]
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Molecular Formula
C18H20N4O4
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Molecular Weight
356.38
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Smiles
O=C1C2=C(C([N+]([O-])=O)=CC=C2NCCCN(C)C)NC3=C1C=C(O)C=C3
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Target
Apoptosis; Topoisomerase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Topoisomerase II inhibitor 3 [CAS 99140-25-7]
Topoisomerase II inhibitor 3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.