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Tubulin-IN-51 [CAS 849550-36-3]
Tubulin-IN-51 [CAS 849550-36-3]
SKU:QM-0014328
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Product Details
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Description
Tubulin-IN-51 is an orally available, potent tubulin inhibitor (IC50 = 31 nM). Tubulin-IN-51 promotes tubulin polymerization in vitro and does not compete with Paclitaxel for binding. Tubulin-IN-51 inhibits the binding of Vinblastine (HY-13780) to tubulin. Tubulin-IN-51 downregulates the proportion of cells in the G1 phase and induces apoptosis. Tubulin-IN-51 inhibits tumor growth in multiple nude mouse xenograft models[1].
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CAS Number
[849550-36-3]
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Molecular Formula
C18H18ClF5N6O
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Molecular Weight
464.82
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Smiles
FC1=CC(OCCCNC)=CC(F)=C1C2=C(N[C@@H](C(F)(F)F)C)N3N=CN=C3N=C2Cl
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Target
Apoptosis; Microtubule/Tubulin
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Shipping Conditions
Room temperature
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Tubulin-IN-51 [CAS 849550-36-3]
Tubulin-IN-51 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.