Tubulin polymerization-IN-79
Tubulin polymerization-IN-79
SKU:QM-0013665
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Product Details
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Description
Tubulin polymerization-IN-79 (Compound C20) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-79 shows potent antiproliferative activity against esophageal cancer cells (e.g., KYSE450, IC50=0.36 μM; EC-109, IC50=0.63 μM) . Tubulin polymerization-IN-79 occupies the colchicine binding site to disrupt microtubule network integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP expression, and inducing G2/M phase arrest and apoptosis in esophageal cancer cells. Tubulin polymerization-IN-79 is promising for research of esophageal cancers[1].
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Molecular Formula
C19H15NO6S
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Molecular Weight
385.39
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Smiles
O=C1C=C(C2=CC=CC=C2O1)OS(=O)(C3=CC=C(C=C3)N4CCCC4=O)=O
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Target
Apoptosis; Hippo (MST) ; Microtubule/Tubulin; YAP
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Shipping Conditions
Room temperature
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Tubulin polymerization-IN-79
Tubulin polymerization-IN-79 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.