Tubulin-IN-53
Tubulin-IN-53
SKU:QM-0013216
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Product Details
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Description
Tubulin-IN-53 is a potent Tubulin inhibitor with an IC50 of 6.06 μM. Tubulin-IN-53 inhibits the polymerization of tubulin by targeting the colchicine binding site of tubulin and destroys the microtubule network. Tubulin-IN-53 induces MCF-7 cell cycle arrest in the G2/M phase and apoptosis, and inhibits cell migration accompanied by the decrease of mitochondrial membrane potential and increase the accumulation of ROS. Tubulin-IN-53 destroys the angiogenesis of human umbilical vein endothelial cells.Tubulin-IN-53 can used for the study of cancers such as breast cancer and lung cancer[1].
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Molecular Formula
C20H16ClNO6
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Molecular Weight
401.8
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Smiles
O=C1OCC2=C1C(C3=CC(OC)=C(OC)C(Cl)=C3)C4=CC5=C(OCO5)C=C4N2
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Target
Apoptosis; Microtubule/Tubulin; Reactive Oxygen Species (ROS)
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Shipping Conditions
Room temperature
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Tubulin-IN-53
Tubulin-IN-53 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.