Tubulin polymerization-IN-76
Tubulin polymerization-IN-76
SKU:QM-0009709
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Product Details
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Description
Tubulin polymerization-IN-76 (compound 20b) is a potent and orally active Tubulin polymerization inhibitor. Tubulin polymerization-IN-76 inhibits Tubulin polymerization with an IC50 of 2.505 μM by acting on the colchicine binding site, thereby disrupting intracellular Microtubule networks and interfering with cell mitosis. Tubulin polymerization-IN-76 demonstrates exceptional efficacy against MGC-803 and HGC-27 cells with IC50s of 1.61 and 1.82 nM, respectively. Tubulin polymerization-IN-76 effectively inhibits the colony formation and cell migration activities, and induces G2/M phase cycle arrest and Apoptosis in MGC-803 and HGC-27 cells.Tubulin polymerization-IN-76 shows a broad-spectrum antiproliferative activity[1].
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Molecular Formula
C20H21N5S
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Molecular Weight
363.48
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Smiles
CN(C1=CC(C=CN2C)=C2C=C1)C3=NC(N4CCCC4)=NC5=C3C=CS5
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Target
Apoptosis; Microtubule/Tubulin; Mitosis
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Shipping Conditions
Room temperature
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Tubulin polymerization-IN-76
Tubulin polymerization-IN-76 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.