Tubulin polymerization/P-gp-IN-1
Tubulin polymerization/P-gp-IN-1
SKU:QM-0015240
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Product Details
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Description
Tubulin polymerization/P-gp-IN-1 is a Tubulin polymerization/P-gp dual inhibitor. Tubulin polymerization/P-gp-IN-1 inhibits tubulin polymerization and induces G2/M arrest and apoptosis. Tubulin polymerization/P-gp-IN-1 reverses MDR by inhibiting P-gp efflux function. Tubulin polymerization/P-gp-IN-1 has dual functions: direct antitumor activity and reversal of P-gp-mediated Cisplatin resistance. Tubulin polymerization/P-gp-IN-1 stable binds to the tubulin CBS (ΔG = −12.4 kcal/mol) and the P-gp hydrophobic lumen (ΔG = −10.8 kcal/mol). Tubulin polymerization/P-gp-IN-1 can be used for the study of drug-resistant cervical cancer[1].
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Molecular Formula
C36H29F3N2O7
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Molecular Weight
658.62
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Smiles
COC1=CC=C(C=C1NC(C2=C3C=CC=CC3=NC(C4=CC(OC(F)(F)F)=CC=C4)=C2)=O)/C=C/C(C5=CC(OC)=C(C(OC)=C5)OC)=O
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Target
Apoptosis; Microtubule/Tubulin; P-glycoprotein
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Shipping Conditions
Room temperature
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Tubulin polymerization/P-gp-IN-1
Tubulin polymerization/P-gp-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.