Type II TRK inhibitor 1 [CAS 2937543-72-9]
Type II TRK inhibitor 1 [CAS 2937543-72-9]
SKU:QM-0067098
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Product Details
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Description
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKAG667C and ETV6-TRKCG696C fusion proteins with IC50s of 6 nM and 1.7 nM, respectively[1]. Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CAS Number
[2937543-72-9]
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Molecular Formula
C35H33F3N8O3
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Molecular Weight
670.68
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Smiles
CN(CCN1)C2=NN3C(C=C2)=NC=C3C#CC4=CC(OCCCCC1=O)=CC(C(NC5=CC(N6C=C(C)N=C6)=CC(C(F)(F)F)=C5)=O)=C4C
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Target
Trk Receptor
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Isoform
TrkA; TrkC
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Type II TRK inhibitor 1 [CAS 2937543-72-9]
Type II TRK inhibitor 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.