Urotensin-II receptor antagonist-1 [CAS 1034708-07-0]
Urotensin-II receptor antagonist-1 [CAS 1034708-07-0]
SKU:QM-0003152
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Product Details
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Description
Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, Ki=16 nM (test on HEK293 cells expressing recombinant human UT receptor) . Urotensin-II receptor antagonist-1 inhibits cytochrome P450 (IC50=0.75 μM, CYP2D6; 1.4 μM, CYP3A4), inhibits κ-opioid receptor (EC50=3.2 μM), targets cardiac sodium channels (Ki=2.5 μM) [1].
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CAS Number
[1034708-07-0]
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Molecular Formula
C25H31Cl2N3O
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Molecular Weight
460.44
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Smiles
CN(CC(N1[C@@H](CN2CCCC2)[C@@H](C3=CC=CC=C3)CCC1)=O)C4=CC=C(Cl)C(Cl)=C4
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Target
Cytochrome P450; Opioid Receptor; Sodium Channel; Urotensin Receptor
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Shipping Conditions
Room temperature
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Urotensin-II receptor antagonist-1 [CAS 1034708-07-0]
Urotensin-II receptor antagonist-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.