VHL Ligand 8 [CAS 2701565-76-4]
VHL Ligand 8 [CAS 2701565-76-4]
SKU:QM-0144286-01
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Product Details
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Description
VHL Ligand 8 is a VHL ligand. VHL Ligand 8 can be used to synthesize ARD-266 , a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. ARD-266 effectively induces degradation of AR protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM[1].
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CAS Number
[2701565-76-4]
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Molecular Formula
C23H29N3O6
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Molecular Weight
443.49
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Smiles
OC(C[C@@H](C1=CC=CC=C1)NC([C@H]2N(C([C@H](C(C)C)C3=CC(C)=NO3)=O)C[C@H](O)C2)=O)=O
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Target
Ligands for E3 Ligase
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Isoform
Von Hippel-Lindau (VHL)
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Purity
98.04
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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VHL Ligand 8 [CAS 2701565-76-4]
VHL Ligand 8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.