VHL Ligand-Linker Conjugates 17
VHL Ligand-Linker Conjugates 17
SKU:QM-0062088
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Product Details
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Description
VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266. ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader[1]. VHL Ligand-Linker Conjugates 17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Molecular Formula
C37H42N4O7
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Molecular Weight
654.75
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Smiles
O=C(C[C@@H](C1=CC=CC=C1)NC([C@H]2N(C([C@H](C(C)C)C3=CC(C)=NO3)=O)C[C@H](O)C2)=O)N(CC4)CCC4C#CC5=CC=C(C(O)=O)C=C5
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Target
E3 Ligase Ligand-Linker Conjugates
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Isoform
Von Hippel-Lindau (VHL)
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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VHL Ligand-Linker Conjugates 17
VHL Ligand-Linker Conjugates 17 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.