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Aurora kinase-IN-1
Aurora kinase-IN-1
SKU:QM-0059126
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Product Details
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Description
Aurora kinase-IN-1 (Compound 9) is a potent inhibitor of aurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also induces apoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents[1].
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Molecular Formula
C30H25Br2N3O5
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Molecular Weight
667.34
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Smiles
CCOC(/C(C1=O)=C/NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC(C4=CC=C(C=C4)Br)=N2)OC5=C1C=C(Br)C=C5
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Target
Apoptosis; Aurora Kinase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Aurora kinase-IN-1
Aurora kinase-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.