Tubulin-IN-59
Tubulin-IN-59
SKU:QM-0015606
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Product Details
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Description
Tubulin-IN-59 (Compound 8g) is an orally active Tubulin inhibitor. Tubulin-IN-59 exhibits potent anti-proliferative activity against HCT116 colorectal cancer, HeLa cervical cancer, and HepG2 liver cancer cell lines, with its IC₅₀ value ranging from 16 to 35 nM. Tubulin-IN-59 arrests HeLa cells in the G2/M phase and induces cell apoptosis. Tubulin-IN-59 demonstrates significant anti-tumor activity in the HT29 human colon cancer mouse xenograft model. Tubulin-IN-59 can be used for the study of colorectal cancer and cervical cancer[1].
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Molecular Formula
C26H22ClF5N6O2
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Molecular Weight
580.94
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Smiles
C[C@H](NC1=C(C2=C(F)C=C(OCCCNC)C=C2F)C(Cl)=NC3=NC(C4=CC=C(OC=C5)C5=C4)=NN13)C(F)(F)F
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Target
Apoptosis; Microtubule/Tubulin
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Shipping Conditions
Room temperature
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Tubulin-IN-59
Tubulin-IN-59 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.