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CDK-IN-18 [CAS 2531743-46-9]
CDK-IN-18 [CAS 2531743-46-9]
SKU:QM-0016773
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Product Details
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Description
CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant and selective inhibitor of CDK2, CDK4, and CDK6. CDK-IN-18 inhibits the activity of cyclin-CDK complexes, blocks phosphorylation of the retinoblastoma protein (pRb), arresting the cell cycle transition from G1 to S phase. CDK-IN-18 is promising for research of cancers, such as breast cancer (especially hormone receptor-positive, HER2-negative type), lung cancer, and colorectal cancer[1][2].
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CAS Number
[2531743-46-9]
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Molecular Formula
C26H30N8O
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Molecular Weight
470.57
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Smiles
CC(C1=C2N(N=C1)C=CC(C3=NC(NC4=CC=C(N5C(C[C@H](CC5)N(C)C)=O)C=N4)=NC=C3)=C2)C
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Target
CDK
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Isoform
CDK2; CDK4; CDK6
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Shipping Conditions
Room temperature
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CDK-IN-18 [CAS 2531743-46-9]
CDK-IN-18 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.