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CDK-IN-9 [CAS 3031561-92-6]
CDK-IN-9 [CAS 3031561-92-6]
SKU:QM-0068961-01
£588.25 GBP
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Product Details
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Description
CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC50 values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II[1].
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CAS Number
[3031561-92-6]
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Molecular Formula
C21H24N8S
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Molecular Weight
420.53
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Smiles
NCCSC1=NC2=C(NN=C2C(NCC3=CC=C(C=C3)N4C=CC=N4)=N1)C5CCC5
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Target
Apoptosis; CDK; DNA/RNA Synthesis; Molecular Glues
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Isoform
CDK12; CDK13; CDK2; CDK5; CDK9
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CDK-IN-9 [CAS 3031561-92-6]
CDK-IN-9 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.