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CDK1/2/4-IN-1 [CAS 2414633-49-9]
CDK1/2/4-IN-1 [CAS 2414633-49-9]
SKU:QM-0066720
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Product Details
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Description
CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
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CAS Number
[2414633-49-9]
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Molecular Formula
C15H16N2O2S
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Molecular Weight
288.36
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Smiles
O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2
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Target
Apoptosis; Bcl-2 Family; Caspase; CDK
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Isoform
Bax; Bcl-2; Caspase 3; CDK1; CDK2; CDK4
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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CDK1/2/4-IN-1 [CAS 2414633-49-9]
CDK1/2/4-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.